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Studies have related the risk of an increased hypotensive response to concomitant administration of selegiline and levodopain patients with cardiovascular risk.

Caution should be exercised in patients receiving MAO inhibitors during general anaesthesia in surgeryMAO inhibitorsincluding selegilinemay potentiate the effects of CNS depressants used for general anaesthesiaTransient respiratory and cardiovascular depressionhypotension and coma have been reportedsee section 4.5

Selegiline should also not be used with other drugs which are also monoamine oxidase inhibitorse.glinezolid.

Eldepryl is contra-indicated in patients receiving treatment with serotonin-agonistse.gsumatriptannaratriptanzolmitriptan and rizatriptan

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndromeThe risk increases if you are also taking other drugs that increase serotoninso tell your doctor or pharmacist of all the drugs you takeGet medical help right away if you develop some of the following symptomshallucinationsunusual restlessnessloss of coordinationfast heartbeatsevere dizzinessunexplained feversevere nausea/vomiting/diarrheatwitching muscle.

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